Detective Lindsay Boxer and her friend Yuki Castellano are out shopping with Yuki's mother Keiko when Keiko drops in the middle of the busy street. It looks like she's had a stroke and Yuki starts to panic. She is rushed to the San Francisco Medical Centre and admitted to the ICU. Over drinks that evening at Susie's, with her friends in the Women's Murder Club, Lindsay learns of a huge malpractice suit against the San Francisco Medical Centre. In the last few years, dozens of patients who were admitted to the emergency room seemed to recover and then died suspicious deaths. Is Yuki's mother safe? In a place where the lives of patients are quite literally in others' hands, will Lindsay and her friends be able to establish who they can trust?